Restylane® and Perlane® are brand names for injectable gel produced by Q-Med, a division of Galderma, Inc., in Uppsala, Sweden. Restylane® and Perlane® products are FDA approved for cosmetic use, and are marketed by Valeant Pharmaceuticals in the United States. The gel is delivered in a sterile syringe for injection into and beneath skin by licensed practitioners. Probably the most common indication for Restylane® and/or Perlane® is direct filling of visible depressions of the skin surface, such as fine lines, creases, wrinkles, and acne scars. An equally common application is for augmentation of upper and lower lips. There are many other “off label” possibilities for use of Restylane® and Perlane®. Both gels are purified formulations of Non-Animal chemically Stabilized Hyaluronic Acid (NASHA™). Hyaluronic acid is a very large glycosaminoglycan (complex carbohydrate) molecule normally distributed throughout human connective tissue and skin. Characteristics of hyaluronic acid that make it a valuable soft tissue filler are its very strong affinity for water, its biocompatibility, and its propensity to stimulate collagen synthesis. Dr. Laverson has seen instances of Restylane® treatment effect lasting for years, possibly due to collagen production at the site of injection beneath a skin crease. The Perlane® hyaluronic acid particulate units are larger than those in Restylane®, but there are more particles per unit volume in Restylane®. Dr. Laverson finds that Perlane® performs best in the deeper subdermis because it is thicker and more structural. Perlane® is thus preferred for deeper creases and folds. Because of its thickness, Perlane® injected at the skin surface may result in visible lumps or irregularities. For superficial creases, Restylane® or another product is preferable. Both Restylane® and Perlane® perform well for lip augmentation.
Dr. Laverson at his Private Feel Beautiful Plastic Surgery Clinic has injected thousands of Restylane® and Perlane® doses, and can attest to the safety and efficacy of these products. They successfully smooth the skin surface to restore more youthful contours. The results are not permanent, but in most cases persist for about six months. Your perception of the result depends on the volume injected (number of milliliters and/or syringes) and product placement. When you arrive in our office for Restylane® or Perlane®, anesthetic will be applied to your skin surface, or local anesthetic injected to numb the area of proposed treatment. When sufficiently numb, the skin surface is disinfected with alcohol, and Dr. Laverson very carefully places the product three dimensionally to achieve for you the best result using the least amount of product possible. Dr. Laverson injects with optical magnification for precision.
Treatment is incremental, and takes 15-30 minutes in most cases. You may look in the mirror intermittently to evaluate the developing result, and direct product placement.
After injection, you see the result immediately. There may be some temporary redness, swelling, and/or bruising of the skin. These resolve in days. Results are generally quite natural, and not noticeable by others. Sometimes, product placement just beneath the skin surface is visible as a translucency or gray colored line. If bothersome, this can be resolved by injection of hyaluronidase (Vitrase®), an enzyme that dissipates hyaluronic acid.